Neeltje van Haren
Contact Details
| Neeltje van Haren Neuroimaging Research Group University Medical Center Utrecht Heidelberglaan 100 3584 CX Utrecht the Netherlands Room: A.01.1.08 Tel.: +31 (0)88 7557130 Fax.: +31 (0)88 7555443 E-mail: n.e.m.vanharen@umcutrecht.nl |
Curriculum Vitae
In 1996 I completed my Master Degree in psychology at the Catholic University in Nijmegen, specialising in neuropsychology. Since 1998, I work at the Rudolf Magnus Institute of Neuroscience, Department of Psychiatry at the University Medical Centre Utrecht. I have contributed to numerous structural MRI studies of patients with schizophrenia and bipolar disorder, and normal controls. I am also involved in (international) twin studies. In 2001-2002 I spent 6 months as an Honorary Research Fellow at the Institute of Psychiatry, London, UK. I defended my thesis on brain volume changes in schizophrenia on October 15th 2004. I remained at the Department of Psychiatry as an assistant professor in Neuroimaging.
Current Research Projects
My main interest is the identification of structural brain abnormalities in schizophrenia and bipolar disorder and how these are modulated by effects related to the illness, e.g., outcome, medication, cannabis, smoking, physical activity and so on. Also, I am interested in the effects of age on the healthy and affected brain. Moreover, I am involved in family and twin studies to examine the influence of genetic and environmental factors on the association between risk to develop schizophrenia or bipolar disorder and the structural brain abnormalities. Finally, in collaboration with prof Henk Aarts, we try to unravel the structural and functional neuronal mechanisms that underly self-agency processes in health and in schizophrenia.
List of publications
Van Haren NE, Kahn RS. A comment on ‘A systematic review of the effects of antipsychotic drugs on brain volume’ by Moncrieff & Leo (2010). Psychol Med. 2010;40;2105-09. Letter to the Editor
First published online 22 September 2010, doi:10.1017/S0033291710001686
Schnack HG, van Haren NE, Brouwer RM, van Baal GC, Picchioni M, Weisbrod M, Sauer H, Cannon TD, Huttunen M, Lepage C, Collins DL, Evans A, Murray RM, Kahn RS, Hulshoff Pol HE. Mapping reliability in multicenter MRI: Voxel-based morphometry and cortical thickness. Hum Brain Mapp. 2010.
Article first published online : 28 JUN 2010, DOI: 10.1002/hbm.20991
Rais M, van Haren NE, Cahn W, Schnack HG, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS. Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia. Eur Neuropsychopharmacol. 2010 Dec;20(12):855-65.
PMID: 20863671.
Van der Schot AC, Vonk R, Brouwer RM, van Baal GC, Brans RG, van Haren NE, Schnack HG, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Genetic and environmental influences on focal brain density in bipolar disorder. Brain. 2010 Oct;133(10):3080-92.
PMID: 20837502.
Ettinger U, Schmechtig A, Toulopoulou T, Borg C, Orrells C, Owens S, Matsumoto K, van Haren NE, Hall MH, Kumari V, McGuire PK, Murray RM, Picchioni M. Prefrontal and striatal volumes in monozygotic twins concordant and discordant for schizophrenia. Schizophr Bull. 2010 Jun 10. [Epub ahead of print]
PMID: 20538831.
Koolschijn PC, van Haren NE, Cahn W, Schnack HG, Janssen J, Klumpers F, Hulshoff Pol HE, Kahn RS. Hippocampal volume change in schizophrenia. J Clin Psychiatry. 2010 Jun;71(6):737-44.
PMID: 20492835.
Van Haren NE, Koolschijn PC, Cahn W, Schnack HG, Hulshoff Pol HE, Kahn RS. Cigarette smoking and progressive brain volume loss in schizophrenia. Eur Neuropsychopharmacol. 2010 Jul;20(7):454-8.
PMID: 20227855.
Koolschijn PC, van Haren NE, Bakker SC, Hoogendoorn ML, Hulshoff Pol HE, Kahn RS. Effects of brain-derived neurotrophic factor Val66Met polymorphism on hippocampal volume change in schizophrenia. Hippocampus. 2010 Sep;20(9):1010-7.
PMID: 19714565.
Van der Schot AC, Vonk R, Brans RG, van Haren NE, Koolschijn PC, Nuboer V, Schnack HG, van Baal GC, Boomsma DI, Nolen WA, Hulshoff Pol HE, Kahn RS. Influence of genes and environment on brain volumes in twin pairs concordant and discordant for bipolar disorder. Arch Gen Psychiatry. 2009 Feb;66(2):142-51.
PMID: 19188536.
Brans RG, van Haren NE, van Baal GC, Schnack HG, Kahn RS, Hulshoff Pol HE. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch Gen Psychiatry. 2008 Nov;65(11):1259-68.
PMID: 18981337.
Brans RG, van Haren NE, van Baal GC, Staal WG, Schnack HG, Kahn RS, Hulshoff Pol HE. Longitudinal MRI study in schizophrenia patients and their healthy siblings. Br J Psychiatry. 2008 Nov;193(5):422-3.
PMID: 18978326.
Van Haren NE, Cahn W, Hulshoff Pol HE, Kahn RS. Schizophrenia as a progressive brain disease. Eur Psychiatry. 2008 Jun;23(4):245-54.
PMID: 18513927.
Van Haren NE, Bakker SC, Kahn RS. Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry. 2008 Mar;21(2):161-7.
PMID: 18332664.
Koolschijn PC, van Haren NE, Hulshoff Pol HE, Kahn RS. Hypothalamus volume in twin pairs discordant for schizophrenia. Eur Neuropsychopharmacol. 2008 Apr;18(4):312-5.
PMID: 18222652.
Van Haren NE, Hulshoff Pol HE, Schnack HG, Cahn W, Brans R, Carati I, Rais M, Kahn RS. Progressive brain volume loss in schizophrenia over the course of the illness: evidence of maturational abnormalities in early adulthood. Biol Psychiatry. 2008 Jan 1;63(1):106-13.
PMID: 17599810.
Ettinger U, Picchioni M, Landau S, Matsumoto K, van Haren NE, Marshall N, Hall MH, Schulze K, Toulopoulou T, Davies N, Ribchester T, McGuire PK, Murray RM. Magnetic resonance imaging of the thalamus and adhesio interthalamica in twins with schizophrenia. Arch Gen Psychiatry. 2007 Apr;64(4):401-9.
PMID: 17404117.
Van Haren NE, Hulshoff Pol HE, Schnack HG, Cahn W, Mandl RC, Collins DL, Evans AC, Kahn RS. Focal gray matter changes in schizophrenia across the course of the illness: a 5-year follow-up study. Neuropsychopharmacology. 2007 Oct;32(10):2057-66.
PMID: 17327887.
Cahn W, van Haren NE, Hulshoff Pol HE, Schnack HG, Caspers E, Laponder DA, Kahn RS. Brain volume changes in the first year of illness and 5-year outcome of schizophrenia. Br J Psychiatry. 2006 Oct;189:381-2.
PMID: 17012664.
Fu CH, Vythelingum GN, Brammer MJ, Williams SC, Amaro E Jr, Andrew CM, Yágüez L, van Haren NE, Matsumoto K, McGuire PK. An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedback. Cereb Cortex. 2006 Jul;16(7):969-77.
PMID: 16195470.
Rijsdijk FV, van Haren NE, Picchioni MM, McDonald C, Toulopoulou T, Hulshoff Pol HE, Kahn RS, Murray R, Sham PC. Brain MRI abnormalities in schizophrenia: same genes or same environment? Psychol Med. 2005 Oct;35(10):1399-409.
PMID: 16164764.
Van Haren NE, Picchioni MM, McDonald C, Marshall N, Davis N, Ribchester T, Hulshoff Pol HE, Sharma T, Sham P, Kahn RS, Murray R. A controlled study of brain structure in monozygotic twins concordant and discordant for schizophrenia. Biol Psychiatry. 2004 Sep 15;56(6):454-61.
PMID: 15364044.
Hulshoff Pol HE, Brans RG, van Haren NE, Schnack HG, Langen M, Baaré WF, van Oel CJ, Kahn RS. Gray and white matter volume abnormalities in monozygotic and same-gender dizygotic twins discordant for schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):126-30.
PMID: 14732591.
Van Haren NE, Cahn W, Hulshoff Pol HE, Schnack HG, Caspers E, Lemstra A, Sitskoorn MM, Wiersma D, van den Bosch RJ, Dingemans PM, Schene AH, Kahn RS. Brain volumes as predictor of outcome in recent-onset schizophrenia: a multi-center MRI study. Schizophr Res. 2003 Nov 1;64(1):41-52.
PMID: 14511800.
Nederlands
Cahn W & van Haren NE. (2005). Schizofrenie: een progressief beloop? In: Schizofrenie 1: Het concept. Ed: Wunderink L. Leusden: Mark Two Communications.
ISBN: 90 77585 31 1
Boks MP, van der Schot A, van Haren NEM. (2008). Neurobiologische aspecten. In: Handboek Bipolaire Stoornis. Editors: R. Kupka, E Knoppert-van der Klein, W. Nolen. Utrecht: De tijdstroom.
ISBN:978 90 5898 1172