neuro STimulation and Registration lab (nSTAR Lab)

The STARlab focusses on the neuroscience of response control in health and disease. We are embedded in the Brain Division of the UMC Utrecht. The development of novel MRI and neurostimulation methods and technology is also a key area of interest. Besides research and development, the STARlab offers training and support in the areas of response control, neuroimaging and brain stimulation, and is active in the domain of knowledge utilization and valorization.

Collaborations:

Current Projects

Cortico-basal control of action selection (NCU)
Cortico-cerebellar networks in learning to select
Measuring striatal lactate as a marker for dopamine (NCU)
Devices for NeuroControl and NeuroRehabilitation (DeNeCor: EU)
Transcranial Magnetic Stimulation during functional MRI

Publications

F.W. Neggers, B.B. Zandbelt, M.S. Schall, J.D. Schall. Comparative diffusion tractography of cortico-striatal motor pathways reveals differences between humans and macaques.J Neurophysiol, in press. Newsflash here
D. de Weijer AD, I.E. Sommer, E.J. Bakker, M. Bloemendaal, C.J. Bakker CJ, D.W. Klomp, S. Bestmann, S.F.W. Neggers (2014). A setup for administering TMS to medial and lateral cortical areas during whole-brain FMRI recording.J Clin Neurophysiol. 31(5):474-87.
D. de Weijer, I.E. Sommer, A. Lotte Meijering, M. Bloemendaal M, S.F.W. Neggers, K Daalman, EH Boezeman (2014). High frequency rTMS; a more effective treatment for auditory verbal hallucinations?Psychiatry Res.224(3):204-10
N. Thakkar, F.M. van den Heiligenberg, R.S. Kahn, S.F.W. Neggers (2014) Frontal-subcortical circuits involved in reactive control and monitoring of gaze.J Neurosci. 25;34(26):8918-29.
Jansma JM, van Raalten TR, Boessen R, Neggers SF, Jacobs RH, Kahn RS, Ramsey NF.fMRI guided rTMS evidence for reduced left prefrontal involvement after task practice. PLoS One. 2013 Dec 20;8(12):e80256
P. Gutteling, S.Y. Park, J.L. Kenemans, S.F.W. Neggers (2013).TMS of the anterior intraparietal area selectively modulates orientation change detection during action preparation. J Neurophysiol. 110(1):33-41.
M. Sharika, S.F.W. Neggers. T.P. Gutteling, S. van der Stigchel, C.H. Dijkerman, A. Murthy (2013). Proactive control of sequential saccades in the human supplementary eye field.Proc Natl Acad Sci U S A. 110(14):E1311-20
E. Bosch, S.F.W. Neggers, S. van der Stigchel (2013). The role of the frontal eye fields in oculomotor competition: image-guided TMS enhances contralateral target selection. Cerebral Cortex 23(4):824-32.
B. Zandbelt, M. Bloemendaal, S.F.W. Neggers, R.S. Kahn, M. Vink (in press). Expectations and violations: delineating the neural network of proactive inhibitory control. Human Brain Mapping
F.W. Neggers, R.M. van Diepen, B.B. Zandbelt, M. Vink, R.C.W. Mandl, T. P. Gutteling (2012). A functional and structural investigation of the human fronto-basal volitional saccade network. PLoS ONE 7(1): e29517. doi:10.1371/journal.pone.0029517
D. de Weijer, S.F. Neggers, K.M. Diederen, R.C. Mandl, R.S. Kahn, H.E. Hulshoff Pol, I.E. Sommer (in press). Aberrations in the arcuate fasciculus are associated with auditory verbal hallucinations in psychotic and in non-psychotic individuals.Human Brain Mapping, doi: 10.1002/hbm.21463
Panouillères, S.F.W. Neggers, T.P. Gutteling, R. Salemme,S. Van der Stigchel, J.N. Van der Geest, M.A. Frens, D. Pélisson (2011). Transcranial Magnetic Stimulation and Motor plasticity in human lateral cerebellum: dual effect on saccadic adaptation.Human Brain Mapping, doi:10.1002/hbm.21301
D. de Weijer, R.C. Mandl, K.M. Diederen, S.F. Neggers, R.S. Kahn, H.E. Pol, I.E. Sommer (2011). Microstructural alterations of the arcuate fasciculus in schizophrenia patients with frequent auditory verbal hallucinations.Schizophr Res 130(1-3):68-77
M.J. Diederen, K. Daalman, A.D. de Weijer, S.F.W. Neggers, W. van Gastel, J.D. Blom, R.S. Kahn and I.E.C. Sommer (in press). Auditory hallucinations elicit similar brain activation in psychotic and non-psychotic individuals. Schizophrenia Bulletin
P. Gutteling, J.L. Kenemans and S.F.W. Neggers (2011). Grasping Preparation Enhances Orientation Change Detection. Plos One 6(3):e17675
E. Struiksma, M.L. Noordzij, S.F. Neggers, W.M. Bosker, A. Postma (2011). Spatial language processing in the blind: evidence for a supramodal representation and cortical reorganization. PLoS One 6(9):e24253
Somers M, Neggers SF, Diederen KM, Boks MP, Kahn RS, Sommer IE (2011). The Measurement of Language Lateralization with Functional Transcranial Doppler and Functional MRI: A Critical Evaluation. Front Hum Neurosci. 5:31.
van Elk , H.T. van Schie,S.F.W. Neggers and H. Bekkering (2010). Neural and temporal dynamics underlying visual selection for action. J Neurophysiol.104(2) : 972-983, 2010
D. de Weijer, R.C.W. Mandl, I.E. Sommer, M. Vink, R.S. Kahn and S.F.W. Neggers (2010). Human fronto-tectal and fronto-striatal-tectal pathways activate differently during anti-saccades. Front. Hum. Neurosci. 4:41. doi:10.3389/fnhum.2010.00041
M. Diederen, S.F.W. Neggers, K. Daalman, J.D. Blom, R. Goekoop, R.S. Kahn, I.E. Sommer (2010).Deactivation of the Parahippocampal Gyrus Preceding Auditory Hallucinations in Schizophrenia. Am J Psychiatry. 167(4):427-35
P. Gutteling, H.M. van Ettinger-Veenstra, J.L. Kenemans, S.F.W. Neggers (2010). Lateralized frontal eye field activity precedes occipital activity shortly before saccades: evidence for cortico-cortical feedback as a mechanism underlying covert attention shifts.J Cogn Neurosci. 22(9):1931-43
M. van Ettinger-Veenstra, W. Huijbers, T.P. Gutteling, M. Vink, J.L. Kenemans, S.F.W. Neggers (2009). fMRI-guided TMS on cortical eye fields: the frontal but not intraparietal eye fields regulate the coupling between visuospatial attention and eye movements. J Neurophysiol. 102(6):3469-80.
van Asselen M, R.P. Kessels, C.J. Frijns, L.J. Kappelle, S.F.W. Neggers, A. Postma (2009). Object-location memory: a lesion-behavior mapping study in stroke patients.Brain Cogn. 71(3):287-94.
B. Zandbelt, T.E. Gladwin, M.A. Raemaekers,M. van Buuren, S.F.W. Neggers, R.S. Kahn,N.F. Ramsey, M. Vink (2008). Within-subject variation in BOLD-fMRI signal changes across repeated measurements: quantification and implications for sample size. NeuroImage 42(1):196-206
F.W. Neggers, E.J. Hermans, N.F. Ramsey (2008). Enhanced sensitivity by fast 3D BOLD fMRI : comparison of SENSE-PRESTO and 2D EPI at 3T. NMR in Biomedicine 21(7):663-76.
E. Sommer, K.M. Diederen, J.D. Blom,A. Willems,L. Kushan, K. Slotema,M.P. Boks,K. Daalman,H.W. Hoek, S.F.W. Neggers,R.S. Kahn (2008). Auditory verbal hallucinations predominantly activate the right inferior frontal area. Brain 131(12):3169-77.
Noordzij ML, Neggers SF, Ramsey NF, Postma A. (2008). Neural correlates of locative prepositions. Neuropsychologia, doi:10.1016/j.neuropsychologia.2007.12.022
F.W. Neggers, W. Huijbers, C.M. Vrijlandt, B.N.S. Vlaskamp, D.J.L.G. Schutter and J.L. Kenemans (2007). TMS pulses on the frontal eye fields break coupling between visuo-spatial attention and eye movements. Journal of Neurophysiology 98(5):2765-2778
Pratt, S.F.W. Neggers (2008). Inhibition of Return in Single and Dual Tasks: Examining Saccadic, Keypress, and Pointing ResponsesPerception & Psychophysics 70(2):257-65.
E. Sommer, K.W. Slotema, A.D. de Weijer,J.D. Blom, K. Daalman, S.F.W. Neggers, M. Somers, W.H. Hoek, A. Aleman, R.S. Kahn (2007). Can fMRI-guidance improve the efficacy of rTMS treatment for auditory verbal hallucinations?Schizofrenia Research 93(1-3):406-8
F.W. Neggers, R.H.J. van der Lubbe, N.F. Ramsey, A. Postma (2006). Interactions between ego- and allocentric neuronal representations of space.NeuroImage 15;31(1):320-31
H.J. Van der Lubbe, S.F.W. Neggers,R. Verleger, J.L. Kenemans (2006). Spatiotemporal overlap between brain activation related to saccade preparation and attentional orienting.Brain Research 1072(1):133-52.
Poljac, S.F.W. Neggers, A.V. van den Berg. (2006) Collision judgment of objects approaching the head.Exp Brain Res., 171(1): 35-46
van Asselen M, R.P. Kessels, S.F.W. Neggers, L.J. Kappelle, C.J. Frijns,A. Postma. (2006) Brain areas involved in spatial working memory.Neuropsychologia, 44(7):1185-94.
van Asselen M, R.P. Kessels, L.J. Kappelle LJ, S.F.W. Neggers,C.J. Frijns,A. Postma A. (2006)Neural correlates of human wayfinding in stroke patients.Brain Res.5;1067(1):229-38.
F.W. Neggers, M.A.H. Raemaekers, E.E.L. Lampmann, A. Postma and N.F. Ramsey (2005). Cortical and subcortical contributions to saccade latency in the human brainEur J Neurosci, 21(10), 2853-2863.
F.W. Neggers, M.L. Scholvinck, R.H. van der Lubbe, A. Postma (2005).Quantifying the interactions between allo- and egocentric representations of space.Acta Psychol, 118(1-2):25-45.
F.W. Neggers, R. Langerak, R. Mandl, D. Schutter, P.J.J. Lemmens, A. Postma & N.F. Ramsey(2004). A stereotactic method for image guided transcranial magnetic stimulation validated with fMRI and motor evoked potentials.NeuroImage 21 (4), 1805-1817
F.W. Neggers, R. Langerak, R. Mandl, D. Schutter and A. Postma (2003). (f)MRI guided TMS using frameless stereotaxy: validation of NeNa with a cortical map of EMG responses. Neuroimage 19, 67–88. (poster at HBM 2003)
L. Noordzij, R.H. van der Lubbe RH, S.F.W. Neggers, A. Postma. (2004). Spatial tapping interferes with the processing of linguistic spatial relations. Can J Exp Psychol. 58(4):259-71
H. Fischer, J. Pratt, & S. F.W. Neggers (2003). Inhibition of Return and Manual Pointing Movements.Perception & Psychophysics, 65:379-387
Hannus, S.F.W. Neggers, F.W. Cornelissen, H. Bekkering (2003). Selective attention for action: New evidence from visual search studies. In G. Humphreys & J. Riddoch (Eds.) Attention and performance: Attention in action
F.W. Neggers and H.Bekkering (2002). Coordinated control of eye and hand movements in dynamic reaching conditions.Human Movement Science, 21,349-376
Stork, S.F.W. Neggers and J. Müsseler (2002). Spatial and temporal features of predictive smooth pursuit eye movements.Human Movement Science, 21,335-348.
F.W. Neggers and H.Bekkering (2002). Neural Control of Movement Synergy. Guest editorial. Human Movement Science, 21,1
Bekkering and S.F.W. Neggers (2002). Visual search is modulated by action intentions.Psychological Science, 13, 370-374
F.W. Neggers and H.Bekkering (2001). Gaze anchoring to a pointing target is present during the entire pointing movement and driven by a non-visual signal.Journal of Neurophysiology, 86: 961-970
Bekkering, S.F.W. Neggers, R. Walker, B. Gleißner, W.H. Dittrich, C. Kennard (2001). The preparation and execution of saccadic eye and goal-directed hand movements in patients with Parkinson’s disease.Neuropsychologia, 39: 173-183
F.W. Neggers and H. Bekkering (2000). Ocular Gaze is Anchored to the Target of an Ongoing Pointing Movement.Journal of Neurophysiology 83: 639-651
F. W. Neggers, H. Bekkering (1999). Integration of visual and somatosensory target information in goal-directed eye and arm movements.Exp Brain Res 125-1, 97-107
C.A.M. Gielen, E. J. Vrijenhoek, T. Flash, and S.F.W. Neggers (1997). Arm Position Constraints During Pointing and Reaching in 3-D Space.Journal of Neurophysiology 78: 660-673

Current Lab Members:

Bas Neggers – Associate Professor
Branco van Hulst – PhD student
Petar Petrov – PhD student
Judith van Leeuwen – Research Assistant
Susanne Asscheman – MSc Student
Jasper Dezwaef – MSc Student

Alumni:

Katy Thakkar	Now Assistant Professor at Michigan State University
Jannie Wijnen	Now PostDoc at the Image Science Institute
Antoin de Weijer	Now PostDoc at FMRIB Center, Oxford University, UK
Tjerk Gutteling	Now PostDoc at Sensorimotor lab, Radboud University Nijmegen, the Netherlands
Kelly Diederen	Now PostDoc at Cambridge Neuroscience, Cambridge University, UK
K.M. Sharika	Now PhD student at the National Brain Research Center, New Delhi, India
Marijn Struiksma	Now PostDoc at Utrecht Institute of Linguistics OTS, Utrecht University, the Netherlands
Fiona Heiligenberg	Now PhD-student working for the FMRIB Centre in Oxford and the Donders Centre for Cognitive Neuroimaging in Nijmegen, the Netherlands.
Jessica Heeman	Now Research Assistant at the Attention Lab, Utrecht University, the Netherlands
Joost Haarsma	Now PhD student in cognitive neuroscience as part of the NSPN project, UK
Mel Batson
Helene Hopman
Lara Rosler	Now doing an internship at the Brain Imaging Centre Frankfurt , Frankfurt, Germany

http://www.nstarlab.nl/