The SCIP lab is interested in applying social cognitive paradigms and link them to neurobiological mechanisms (e.g. structural and functional MRI) in healthy individuals, those at risk for psychosis (e.g. siblings and offspring of patients) and patients with a psychotic illness (in particular schizophrenia and bipolar disorder), with the aim of understanding (abnormal) social functioning. We are particularly interested in social cognitive measures that focus on self-referential processes, such as self-agency, and processes related to distinguish between self and other, such as joint action, emotional contagion, and multisensory integration.
Collaborations
We closely collaborate with Prof. Henk Aarts and his lab (Social and behavioral sciences at UU), Prof. Manon Hillegers and her lab (BRIDGE at UMCU and Erasmus Medical Centre), Dr. Matthijs Vink (fMRI at UU), and Dr. Anouk van der Weiden (Clinical and healthy psychology at UU).
Moreover, we actively participate in the ENIGMA consortium, a worldwide initiative that brings together researchers in imaging genomics to understand brain structure, function, and disease, based on brain imaging and genetic data (http://enigma.ini.usc.edu).
Key Publications
- For all publication of NEM van Haren, see: https://www.ncbi.nlm.nih.gov/pubmed/?term=van+haren+n+%5Bau%5D
- Prikken M, van der Weiden A, Renes RA, Koevoets MG, Heering HD, Kahn RS, Aarts H, van Haren NE. Abnormal agency experiences in schizophrenia patients: Examining the role of psychotic symptoms and familial risk. Psychiatry Res. 2017 Apr;250:270-276.
- Van Haren NE, Kahn RS. Progressive brain tissue loss in schizophrenia. Schizophr Res. 2016 Jun;173(3):121-3.
- Bootsman F, Kemner SM, Hillegers MH, Brouwer RM, Vonk R, van der Schot AC, Hulshoff Pol HE, Nolen WA, Kahn RS, van Haren NE. The association between hippocampal volume and life events in healthy twins. Hippocampus. 2016 Aug;26(8):1088-95.
- Schnack HG, van Haren NE, Nieuwenhuis M, Hulshoff Pol HE, Cahn W, Kahn RS. Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study. Am J Psychiatry. 2016 Jun 1;173(6):607-16.
- Heering HD, van Haren NE; G.R.O.U.P investigators. Social functioning in patients with a psychotic disorder and first rank symptoms. Psychiatry Res. 2016 Mar 30;237:147-52.
- Renes RA, Vink M, van der Weiden A, Prikken M, Koevoets MG, Kahn RS, Aarts H, van Haren NE. Impaired frontal processing during agency inferences in schizophrenia. Psychiatry Res. Neuroimage 2016 Feb 28;248:134-41.
- Maat A, van Haren NE, Bartholomeusz CF, Kahn RS, Cahn W. Emotion recognition and theory of mind are related to gray matter volume of the prefrontal cortex in schizophrenia. Eur Neuropsychopharmacol. 2016 Feb;26(2):255-64.
- van der Weiden A, Aarts H, Prikken M, van Haren NE. Individual differences in action co-representation: not personal distress or subclinical psychotic experiences but sex composition modulates joint action performance. Exp Brain Res. 2016 Feb;234(2):499-510.
- Renes RA, van Haren NE, Aarts H. Attentional control and inferences of agency: Working memory load differentially modulates goal-based and prime-based agency experiences. Conscious Cogn. 2015 Dec 15;38:38-49.
- Bootsman F, Brouwer RM, Kemner SM, Schnack HG, van der Schot AC, Vonk R, Hillegers MH, Boomsma DI, Hulshoff Pol HE, Nolen WA, Kahn RS, van Haren NE. Contribution of genes and unique environment to cross-sectional and longitudinal measures of subcortical volumes in bipolar disorder. Eur Neuropsychopharmacol. 2015 Dec;25(12):2197-209.
- Collin G, van den Heuvel MP, Abramovic L, Vreeker A, de Reus MA, van Haren NE, Boks MP, Ophoff RA, Kahn RS. Brain network analysis reveals affected connectome structure in bipolar I disorder. Hum Brain Mapp. 2016 Jan;37(1):122-34.
- van Haren NE, Schnack HG, Koevoets MG, Cahn W, Hulshoff Pol HE, Kahn RS. Trajectories of subcortical volume change in schizophrenia: A 5-year follow-up. Schizophr Res. 2016 Jun;173(3):140-5.
- van der Weiden A, Prikken M, van Haren NE. Self-other integration and distinction in schizophrenia: A theoretical analysis and a review of the evidence. Neurosci Biobehav Rev. 2015 Oct;57:220-37.
- Heering HD, Koevoets GJ, Koenders L, Machielsen MW, Meijer CJ, Kubota M, de Nijs J, Cahn W, Hulshoff Pol HE, de Haan L, Kahn RS, van Haren NE. Structural MRI Differences between Patients with and without First Rank Symptoms: A Delusion? Front Psychiatry. 2015 Jul 29;6:107.
- Kubota M*, van Haren NE*, Haijma SV, Schnack HG, Cahn W, Hulshoff Pol HE, Kahn RS. Association of IQ Changes and Progressive Brain Changes in Patients With Schizophrenia. JAMA Psychiatry. 2015 Aug;72(8):803-12.
- Renes RA, van der Weiden A, Prikken M, Kahn RS, Aarts H, van Haren NE. Abnormalities in the experience of self-agency in schizophrenia: A replication study. Schizophr Res. 2015 May;164(1-3):210-3
- Heering HD, Janssens M, Boyette LL, van Haren NE; G.R.O.U.P investigators. Remission criteria and functional outcome in patients with schizophrenia, a longitudinal study. Aust N Z J Psychiatry. 2014 [Epub ahead of print]
- Renes RA, van Haren NE, Aarts H, Vink M. An exploratory fMRI study into inferences of self-agency. Soc Cogn Affect Neurosci. 2014 [Epub ahead of print]
- Heering HD, van Haren NE, Derks EM; GROUP Investigators. A two-factor structure of first rank symptoms in patients with a psychotic disorder. Schizophr Res. 2013 Jul;147(2-3):269-74.
- Hedman AM, van Haren NE, van Baal CG, Kahn RS, Hulshoff Pol HE. IQ change over time in schizophrenia and healthy individuals: a meta-analysis. Schizophr Res. 2013 May;146(1-3):201-8
- Renes RA, Vermeulen L, Kahn RS, Aarts H, van Haren NE. Abnormalities in the establishment of feeling of self-agency in schizophrenia. Schizophr Res. 2013 Jan;143(1):50-4.
- van Haren N, Cahn W, Hulshoff Pol H, Kahn R. Confounders of excessive brain volume loss in schizophrenia. Neuroscience and Biobehavioral Reviews 37 (2013), 2418-2423.
- Haijma S, van Haren N, Cahn W, Koolschijn PC, Hulshoff Pol H, Kahn R. Brain volumes in schizophrenia and the impact of antipsychotic drugs and intelligence: a meta-analysis in over 18,000 subjects. Schizophr Bull. 2013 Sep;39(5):1129-38.
- Hedman AM, van Haren NE, van Baal GC, Brans RG, Hijman R, Kahn RS, Hulshoff Pol HE. Is there change in intelligence quotient in chronically ill schizophrenia patients? A longitudinal study in twins discordant for schizophrenia. Psychol Med. 2012 Apr 13:1-7.
- Aarts H, Bijleveld E, Custers R, Dogge M, Deelder M, Schutter D, Haren NE. Positive priming and intentional binding: eye-blink rate predicts reward information effects on the sense of agency. Soc Neurosci. 2012;7(1):105-12.
- van Haren NE, Schnack HG, Cahn W, van den Heuvel MP, Lepage C, Collins L, Evans AC, Hulshoff Pol HE, Kahn RS. Changes in cortical thickness during the course of illness in schizophrenia. Arch Gen Psychiatry. 2011 Sep;68(9):871-80.
- Stone JM, Abel KM, Allin MP, van Haren N, Matsumoto K, McGuire PK, Fu CH. Ketamine-induced disruption of verbal self-monitoring linked to superior temporal activation. Pharmacopsychiatry. 2011 Jan;44(1):33-48. Erratum in: Pharmacopsychiatry. 2011 Jan;44(1):41
Current Lab Members
- Neeltje van Haren (PI) - Associate Professor
- Loek Brinkman – Post Doc (UU)
- Merel Prikken – PhD student
- Martijn Koevoets – PhD student
- Sonja de Zwarte – PhD student
- Nikita Setiaman – PhD student
- Natascha den Bleijker – Research Assistant
- Heleen Baalbergen – Research Assistant
- Elizabeth Buimer – Research Assistant
Alumni
- Eline Koppenol (2015)
- Jet Heering (PhD, 2015), now psychologist at GGZ inGeest, Amsterdam
- Robert Renes (PhD, 2016), now tutor and instructor at University College Utrecht
- Anouk van der Weiden (2015), now post-doc at Utrecht University
- Philippine van der Flier (2016)
- Floor van der Doef (2016)